Autologous stem cell transplantation for crohn's disease
Record ID 32013000542
English
Authors' recommendations:
Autologous stem cell transplantation (ASCT) for patients with Crohn's disease (CD) involves harvesting hematopoietic stem cells, or progenitor cells, from the patient's own bone marrow (autologous bone marrow-derived mesenchymal stem cells transplantation) or peripheral blood (autologous peripheral blood stem cell transplantation) during CD remission and reinfusing the hematopoietic stem cells following bone marrow ablation with chemotherapy and/or radiotherapy. The goal is to restore hematopoietic (blood-forming) function. ASCT may also involve harvesting adipose tissue-derived stem cells (autologous adipose tissue-derived stem cell transplantation) from the patient's own lipoaspirate and injecting them directly into the CD-associated fistula wall to aid in tissue recovery and regeneration due to the stem cells' ability to suppress inflammation and potential for differentiation.
Details
Project Status:
Completed
Year Published:
2013
URL for published report:
The report may be purchased from: http://www.hayesinc.com/hayes/crd/?crd=15173
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Transplantation, Autologous
- Stem Cell Transplantation
Contact
Organisation Name:
HAYES, Inc.
Contact Address:
157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218
Contact Name:
saleinfo@hayesinc.com
Contact Email:
saleinfo@hayesinc.com
Copyright:
2013 Winifred S. Hayes, Inc
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.