[Efficacy of atomoxetine and methylphenidate in attention deficits hyperactivity disorder in adults: a rapid review]

Jang BH, Lee HY, Jung YJ, An JH
Record ID 32013000535
Original Title: 성인 주의력결핍과잉행동장애에서 Atomoxetine, Methylphenidate의 효과
Authors' recommendations: The research was carried out using the basic existing systematic review framework suggested by the Agency for Healthcare Research and Quality (AHRQ 2009). A final twenty-one existing systematic reviews evaluated the adequacy and quality of the literature using AMSTAR (Assessment of Multiple Systematic Reviews). However, twenty of them did not score high enough grades in their quality, and the last one had a high grade but the research results were unacceptable because they could have been out of date since the review was published in 1999. Thus, instead of using the existing systematic reviews, a de novo systematic review of randomized controlled trials on atomoxetine/methylphenidate was performed, according to the framework of this research. To conduct the de novo rapid review, a total of 39 studies were selected. After reviewing these studies on atomoxetine and methylphenidate, most of the studies concluded that both medications effectively relieved adult ADHD symptoms. There were some adverse events such as nausea, headache, and loss of appetite, but the symptoms were not severe, and these symptoms disappeared after stopping the medication. Thus, using these two medications for adult ADHD is considered appropriate.
Project Status: Completed
Year Published: 2012
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: South Korea
MeSH Terms
  • Adult
  • Propylamines
  • Adrenergic Uptake Inhibitors
  • Methylphenidate
Organisation Name: National Evidence-based healthcare Collaborating Agency
Contact Address: National Evidence-based Healthcare Collaborating Agency (NECA), 3~5F Health and Welfare Social Administration B/D, 400 Neungdong-ro, Gwangjin-gu, Seoul, Korea.
Contact Name: int@neca.re.kr
Contact Email: int@neca.re.kr
Copyright: National Evidence-based Healthcare Collaborating Agency (NECA)
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