Original Title: 성인 주의력결핍과잉행동장애에서 Atomoxetine, Methylphenidate의 효과

Authors' recommendations: The research was carried out using the basic existing systematic review framework suggested by the Agency for Healthcare Research and Quality (AHRQ 2009). A final twenty-one existing systematic reviews evaluated the adequacy and quality of the literature using AMSTAR (Assessment of Multiple Systematic Reviews). However, twenty of them did not score high enough grades in their quality, and the last one had a high grade but the research results were unacceptable because they could have been out of date since the review was published in 1999. Thus, instead of using the existing systematic reviews, a de novo systematic review of randomized controlled trials on atomoxetine/methylphenidate was performed, according to the framework of this research. To conduct the de novo rapid review, a total of 39 studies were selected. After reviewing these studies on atomoxetine and methylphenidate, most of the studies concluded that both medications effectively relieved adult ADHD symptoms. There were some adverse events such as nausea, headache, and loss of appetite, but the symptoms were not severe, and these symptoms disappeared after stopping the medication. Thus, using these two medications for adult ADHD is considered appropriate.

Project Status: Completed

Year Published: 2012

URL for published report: https://www.neca.re.kr/lay1/program/S1T11C145/report/view.do?seq=2

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: South Korea

Organisation Name: National Evidence-based healthcare Collaborating Agency

Contact Address: National Evidence-based Healthcare Collaborating Agency (NECA), 3~5F Health and Welfare Social Administration B/D, 400 Neungdong-ro, Gwangjin-gu, Seoul, Korea.

Contact Name: int@neca.re.kr

Contact Email: int@neca.re.kr

Copyright: National Evidence-based Healthcare Collaborating Agency (NECA)