What is the clinical and cost effectiveness of human papillomavirus (HPV) testing, followed by liquid-based cytology triage of positive results, in primary screening for cervical cancer?

Abbotts J, McIntosh H
Record ID 32013000464
English
Authors' recomendations: In primary screening for cervical cancer, HPV testing followed by conventional cytology triage of positive results is highly sensitive and highly specific for the detection of CIN3+ (CIN3, carcinoma in situ and cervical cancer). HPV testing followed by conventional cytology triage of positive results is more sensitive than cytology alone for the detection of CIN3+. In women 35 years and older, HPV testing followed by conventional cytology triage of positive results is more specific than cytology alone. More evidence is required to establish relative specificity in women aged 20–35 years. Primary HPV testing allows the screening interval to be safely extended to at least 6 years. Primary HPV testing followed by conventional cytology triage of positive results, with a 5-year screening interval, may be cost effective compared with 3-yearly conventional cytology.
Details
Project Status: Completed
Year Published: 2012
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Scotland, United Kingdom
MeSH Terms
  • Papillomavirus Infections
  • Vaginal Smears
  • Mass Screening
  • Cost-Benefit Analysis
  • Cytodiagnosis
Contact
Organisation Name: Scottish Health Technologies Group
Contact Address: Scottish Health Technologies Group, Delta House, 50 West Nile Street, Glasgow, G1 2NP Tel: 0141 225 6998
Contact Name: his.shtg@nhs.scot
Contact Email: his.shtg@nhs.scot
Copyright: Healthcare Improvement Scotland
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.