Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review

Jobanputra P, Parry D, Fry-Smith A, Burls A
Record ID 32001000083
Authors' objectives:

The aim of this report is to: - describe the types of knee disease for which autologous chondrocyte transplantation (ACT) has been applied, the natural history and epidemiology of these conditions, and alternative treatment options - determine long-term clinical outcomes following ACT and other surgical procedures for knee cartilage defects - examine the economic evidence and consider the economic gains resulting from ACT.

Authors' results and conclusions: The outcome of ACT surgery was rated as good or excellent by approximately 70% of patients 2 years after treatment. Approximately 16% of patients required further arthroscopic surgical procedures during follow-up, and treatment was judged to have failed in 37% of patients. For comparator treatments, the outcome was rated as good or excellent in 10-95% of patients 2 years after treatment.
Authors' recommendations: The reported literature on ACT and comparators is subject to bias because of the inherent weaknesses of case series. In addition, the long-term impact of conventional surgical treatments or no surgical treatment is poorly documented. The cost-effectiveness analysis is similarly limited by the poverty of the effectiveness data on both ACT and comparators, the lack of long-term follow-up and the lack of empirical data for some of the parameters in the model used.
Authors' methods: Systematic review
Project Status: Completed
URL for project: http://www.hta.ac.uk/1175
Year Published: 2001
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Costs and Cost Analysis
  • Chondrocytes
  • Knee Injuries
  • Osteoarthritis, Knee
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
Copyright: 2009 Queen's Printer and Controller of HMSO
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