Authors' objectives: The purpose of this report is to update the previous review of the literature on ADM use for breast reconstruction and to summarize the data on infection rate and aesthetic outcomes recorded at the McGill University Health Centre (MUHC).

Authors' recommendations: Based on observational studies, the evidence suggests that there is a higher risk of exposure of the breast implant, infection, seroma, and higher overall complication rates for two-stage breast reconstruction with ADM. However, contemporary experience at the MUHC and at one other centre that was consulted does not confirm an association between ADM use and higher complication rates. The available evidence suggests that the risk of capsular contracture appears to be lower and aesthetic outcomes superior with the use of ADM for breast reconstruction following cancer surgery. The quality of this evidence is poor. However, objective evidence on aesthetic outcome is difficult to collect and it is possible that no better evidence will be developed.

Project Status: Completed

Year Published: 2012

URL for published report: http://www.mcgill.ca/tau/files/tau/muhc_tau_2012_59_dermalmatrix.pdf

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Canada

Organisation Name: Technology Assessment Unit of the McGill University Health Centre (MUHC)

Contact Address: Technology Assessment Unit of the MUHC, Centre for Outcomes Research and Evaluation (CORE), Research Institute of the McGill University Health Centre, 5252 boul. de Maisonneuve, Bureau 3F.50, Montreal, Quebec H4A 3S5

Contact Name: nandini.dendukuri@mcgill.ca

Contact Email: nandini.dendukuri@mcgill.ca

Copyright: Technology Assessment Unit of the McGill University Health Centre (MUHC)