Authors' recommendations: A hernia is a bulge or protrusion of an organ through a muscle or other structure that normally serves to keep it contained. Hernias can occur in many places, including the abdomen, groin, diaphragm, brain, and at the site of a previous operation or injury. Surgical approaches to repair a hernia are primary suture repair, autologous flap mobilization and implantation, primary closure reinforced with a mesh, or bridging unopposed fascial edges with a mesh. Prosthetics used for hernia repair are broadly classified into three categories: synthetic polymers, composites, and biologic meshes. Biologic meshes are acellular dermal matrices derived from collagen-rich tissues of bovine, porcine, or human sources. They are decellularized with sodium deoxycholate or a similar solvent, which yields a matrix of collagen, elastin, and laminin that serves as supporting strattice for cellular repopulation and neovascularization. The acellular meshes may be crosslinked, which inhibits collagen degradation by blocking collagenase-binding sites, thereby allowing the mesh to maintain its structure for a longer period with slower incorporation into the adjacent tissue. The main advantage of biologic meshes is their diminished foreign body response as compared with their synthetic counterparts, which support their use in contaminated or infected surgical wounds.

Project Status: Completed

Year Published: 2012

URL for published report: The report may be purchased from:http://www.hayesinc.com/hayes/crd/?crd=14172

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: United States

Organisation Name: HAYES, Inc.

Contact Address: 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218

Contact Name: saleinfo@hayesinc.com

Contact Email: saleinfo@hayesinc.com

Copyright: 2012 Winifred S. Hayes, Inc