[Efficacy and safety of genetic tests for screening of colorectal cancer]
Pérez Alonso A, Llanos Méndez, A
Record ID 32012000844
Spanish
Authors' recommendations:
RESULTS:
The reviewed studies offered high values for specificity, exceeding 90% for the majority of the genes studied. Results superior to those achieved with regards to the sensitivity, therefore showed a greater capacity to rule in the disease than to rule out it.
The gene that was found to be of the greatest diagnostic accuracy was gene SEPT9, with specificity values between 90 and 96% and sensitivity between 40 and 75%, showing a strong-conclusive diagnostic evidence in confirming the existence of colorectal cancer (positive likelihood ratios of between 5.8 and 18.75), although with values to rule out the disease that were only acceptable (negative likelihood ratios between 0.26 and 0.63).
CONCLUSION:
Nevertheless, before genetic blood tests can be incorporated into the health system as part of a screening program, it is essential to resolve outstanding problems such as the appropriate selection of the target population, the test obtaining a correct classification of the patients to study by means of an appropriate configuration of the final gene or panel of genes, the planning of a working protocol in which the correct multidisciplinary coordination is achieved; and finally the benefit that would be obtained with regards to the changes in the prognosis and its repercussion on the disease and/or death rate.
Details
Project Status:
Completed
URL for project:
https://www.aetsa.org/publicacion/eficacia-y-seguridad-de-los-tests-geneticos-para-el-cribado-de-cancer-colorrectal/
Year Published:
2012
URL for published report:
https://www.aetsa.org/download/publicaciones/antiguas/AETSA_2011-2-1_CribadoGen_CaColon.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Spain
MeSH Terms
- Colorectal Neoplasms
- Mass Screening
Contact
Organisation Name:
Andalusian Health Technology Assessment Area
Contact Address:
Area de Evaluacion de Tecnologias Sanitarias Sanitarias de Andalucia (AETSA) Avda. Innovación, s/n Edificio Arena 1. Sevilla (Spain) Tel. +34 955 006 309
Contact Name:
aetsa.csalud@juntadeandalucia.es
Contact Email:
aetsa.csalud@juntadeandalucia.es
Copyright:
Andalusian Agency for Health Technology Assessment (AETSA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.