Modafinil for sleep disorders and fatigue secondary to multiple sclerosis: a review of the clinical efficacy and safety
CADTH
Record ID 32012000697
English
Authors' recommendations:
No conclusions can be drawn on the efficacy of modafinil compared to methylphenidate or amphetamines due to the absence of head-to-head clinical trials. Relative to placebo, modafinil was associated with improvements in sleepiness and some domains of health related quality of life, in patients with narcolepsy however, the clinical importance of these findings are unclear. No clear benefit was found with modafinil in patients with fatigue related to MS. The data available were insufficient to draw conclusions on the safety of modafinil in patients with sleep disorders or MS.
Details
Project Status:
Completed
Year Published:
2012
URL for published report:
http://www.cadth.ca/media/pdf//htis/aug-2012/RC0372%20Modafinil%20Final.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Humans
- Sleep Wake Disorders
- Benzhydryl Compounds
- Fatigue
- Multiple Sclerosis
Contact
Organisation Name:
Canadian Agency for Drugs and Technologies in Health
Contact Address:
600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;
Contact Name:
requests@cadth.ca
Contact Email:
requests@cadth.ca
Copyright:
Canadian Agency for Drugs and Technologies in Health (CADTH)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.