Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence
Record ID 32012000679
Authors' recommendations: The evidence base around a watchful dose threshold for morphine or equivalent opioid dosing was limited in both quality and quantity. The evidence to support a watchful dose of morphine or morphine equivalent opioid dosing of greater than 200 mg/day in chronic non-cancer pain (CNCP) is limited in both quality and quantity; however, there is also little evidence to support a lower threshold dose. The paucity of evidence for watchful dosing is likely reflective of larger gaps in evidence in the topic of CNCP management in general, including around the appropriate use of opioids.
Project Status: Completed
Year Published: 2012
URL for published report: http://www.cadth.ca/media/pdf/htis/june-2012/RC0353%20Watchful%20Dose%20Final.pdf
English language abstract: An English language summary is available
Publication Type: Not Assigned
- Chronic Pain
- Dose-Response Relationship, Drug
Organisation Name: Canadian Agency for Drugs and Technologies in Health
Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;
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Copyright: Canadian Agency for Drugs and Technologies in Health (CADTH)
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