Codeine and acetaminophen for pain relief: a review of the clinical efficacy and safety
CADTH
Record ID 32012000672
English
Authors' recommendations:
Based on this review, both codeine and acetaminophen/codeine provide better chronic pain relief than placebo. Chronic use of acetaminophen at doses higher than 2000 mg per day may be associated with increased risk of gastrointestinal events, liver toxicity, and renal dysfunction or failure. This review found evidence of increased risk of adverse events for patients treated with codeine or acetaminophen/codeine combination products compared to placebo. Acetaminophen/codeine treatment for post-operative pain was found to be associated with a higher risk of adverse events compared to placebo. No evidence was found on relative safety of different doses of either codeine or acetaminophen/codeine combination products.
Details
Project Status:
Completed
Year Published:
2012
URL for published report:
http://www.cadth.ca/media/pdf/htis/april-2012/RC0344%20Pain%20Medication%20Dosing%20Final.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Acetaminophen
- Analgesics, Opioid
- Analgesics, Non-Narcotic
- Pain
Contact
Organisation Name:
Canadian Agency for Drugs and Technologies in Health
Contact Address:
600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;
Contact Name:
requests@cadth.ca
Contact Email:
requests@cadth.ca
Copyright:
Canadian Agency for Drugs and Technologies in Health (CADTH)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.