Noninvasive positive pressure ventilation for chronic respiratory failure patients with stable chronic obstructive pulmonary disease (COPD): an evidence-based analysis
COPD Working Group
Record ID 32012000632
English
Authors' objectives:
The objective of this health technology assessment was to determine the effectiveness and costeffectiveness of noninvasive ventilation for stable chronic obstructive pulmonary disease (COPD).
Authors' recommendations:
The following conclusions refer to stable, severe COPD patients receiving usual care.
Short-Term Studies
- Based on low quality of evidence, there is a beneficial effect of NPPV compared with no ventilation on oxygen gas exchange, carbon dioxide gas exchange, and exercise tolerance measured using the 6 minute walking test.
- Based on very low quality of evidence, there is no effect of NPPV therapy on lung function measured as forced expiratory volume in 1 second (Type II error not excluded).
Long-Term Studies
- Based on moderate quality of evidence, there is no effect of NPPV therapy for the outcomes of mortality, lung function measured as forced expiratory volume in 1 second, and exercise tolerance measured using the 6 minute walking test.
- Based on low quality of evidence, there is no effect of NPPV therapy for the outcomes of oxygen gas exchange and carbon dioxide gas exchange (Type II error not excluded).
Qualitative Assessment
- Based on low quality of evidence, there is a beneficial effect of NPPV compared with no ventilation for dyspnea based on reduced Borg score or Medical Research Council dyspnea score.
- Based on moderate quality of evidence, there is no effect of NPPV therapy for hospitalizations.
- Health-related quality of life could not be evaluated.
Details
Project Status:
Completed
Year Published:
2012
URL for published report:
http://www.hqontario.ca/en/mas/tech/pdfs/2012/rev_COPD_Ventilation_Chronic_March.pdf
URL for additional information:
http://www.hqontario.ca/en/mas/mas_ohtas_tech_copd_ventilation_chronic_20120313.html
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Humans
- Positive-Pressure Respiration
- Pulmonary Disease, Chronic Obstructive
- Respiratory Insufficiency
Contact
Organisation Name:
Medical Advisory Secretariat
Contact Address:
Medical Advisory Secretariat, 20 Dundas Street West, 10th Floor, Toronto, ON M5G 2N6 CANADA. Tel: 416-314-1092l; Fax: 416-325-2364;
Contact Name:
MASinfo.moh@ontario.ca
Contact Email:
MASinfo.moh@ontario.ca
Copyright:
Medical Advisory Secretariat, Ontario Ministry of Health and Long-Term Care (MAS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.