[Systematic review of the usefulness of the determination of exhaled nitric oxide in the control of infantile and juvenile asthma}

García Estepa R, Praena Crespo M, Flores Moreno S, Ruiz-Canela Cáceres J, Martín Muñoz P, Beltrán Calvo C
Record ID 32012000488
Spanish
Authors' recommendations: RESULTS The literature search identified 7 studies that assessed the usefulness of nitric oxi¬de in the management of infantile-juvenile asthma. Also located were 4 clinical trials, 1 systematic review and 2 health technology assessment reports. The selec¬ted trials, with the exception of one, had some methodological weaknesses, as did the health technology assessment reports. However, the systematic review, despite several limitations, had a high methodological quality. The selected studies do not provide significant correlations between FENO levels and clinically relevant outcomes such as optimal therapy, reduction of ICS doses or a more appropriate use of the drug combination, reduced exacerbations or decrease in symptoms. Furthermore, in the diversity of secondary outcomes posed by each study, significant differences were detected only in some of them, from which it might be considered that the usefulness of FENO levels for the control of infant-juvenile patients is not fully demonstrated. CONCLUSIONS The clinical validity of using the determination of nitric oxide levels to control infantile and juvenile asthma has not been conclusively established. • According to available evidence, the use of the determination of nitric oxide levels does not improve important outcomes in asthma such as: re¬duction of symptoms and prevention of crisis or exacerbations, improved lung function and reduction or better management of inhaled corticoste¬roid treatment, compared to the usual practice, based on symptoms with or without spirometry. • The studies analysed did not demonstrate the clinical usefulness of deter¬mining nitric oxide levels in the control of infantile-juvenile asthma.
Details
Project Status: Completed
URL for project: https://www.aetsa.org/publicacion/revision-sistematica-de-la-utilidad-de-la-determinacion-del-oxido-nitrico-espirado-en-el-control-del-asma-infanto-juvenil/
Year Published: 2011
URL for published report: https://www.aetsa.org/download/publicaciones/antiguas/AETSA_2009-7_Oxido_Nitroso_asma.pdf
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Spain
MeSH Terms
  • Nitric Oxide
  • Child
  • Child, Preschool
  • Asthma
  • Fractional Exhaled Nitric Oxide Testing
  • Breath Tests
Contact
Organisation Name: Andalusian Health Technology Assessment Area
Contact Address: Area de Evaluacion de Tecnologias Sanitarias Sanitarias de Andalucia (AETSA) Avda. Innovación, s/n Edificio Arena 1. Sevilla (Spain) Tel. +34 955 006 309
Contact Name: aetsa.csalud@juntadeandalucia.es
Contact Email: aetsa.csalud@juntadeandalucia.es
Copyright: <p>Andalusian Agency for Health Technology Assessment (AETSA)</p>
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.