Remicade (Infliximab; Janssen Biotech Inc., a Johnson&Johnson Company) for treatment of pulmonary sarcoidosis
Record ID 32012000166
English
Authors' recommendations:
Sarcoidosis is an inflammatory multisystem disorder of unknown etiology that is characterized by the development of noncaseating granulomas (collections of immune cells and other cells) in one or more organ systems. In theory, the disorder is believed to be the result of an immune-mediated response to an unknown antigen. The disease may remit spontaneously with or without treatment, or it may progress to chronic, debilitating disease. Approximately 25% of patients with sarcoidosis have a chronic form of the disease and require long-term therapy to avoid progressive organ dysfunction. The overall mortality rate for sarcoidosis ranges from 1% to 5%; however, for chronic sarcoidosis, the mortality rate is 12%. Sarcoidosis primarily affects the lungs, with more than 90% of patients with the disease presenting with lung involvement. Symptoms of pulmonary sarcoidosis are dyspnea, cough, and retrosternal chest discomfort. The greatest risk associated with pulmonary sarcoidosis is the development of irreversible pulmonary fibrosis, which is the leading cause of sarcoidosis-related death in the United States. While no standardized treatment regimens for pulmonary sarcoidosis have been established, first-line treatment includes high-dose oral or inhaled corticosteroids, although their long-term efficacy for suppressing granulomatous inflammation associated with pulmonary sarcoidosis have not been established. In addition, their cumulative toxicity and relative contraindications render their prolonged use problematic. Hence, there is growing interest in alternative treatment options for sarcoidosis.
Details
Project Status:
Completed
Year Published:
2011
URL for published report:
http://www.hayesinc.com/hayes/crd/?crd=13070
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Anti-Inflammatory Agents
- Pulmonary Embolism
- Sarcoidosis, Pulmonary
Contact
Organisation Name:
HAYES, Inc.
Contact Address:
157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218
Contact Name:
saleinfo@hayesinc.com
Contact Email:
saleinfo@hayesinc.com
Copyright:
2011 Winifred S. Hayes, Inc
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