The use of Lactobacillus probiotics in the prevention of antibiotic associated clostridium difficile diarrhea
Sinclair A, Xie X, Dendukuri N
Record ID 32012000046
English
Authors' objectives:
Clostridium difficile diarrhea (CDAD) is the most common nosocomial diarrhea, prolonging hospitalization and for some patients leading to colectomy or death. It is strongly associated with antibiotic use, and has been attributed to perturbation of the normal intestinal biota; for this reason there has been an interest in the effectiveness of live cultures (probiotics) in preventing CDAD. The TAU reviewed the use of probiotics in CDAD in 2005 and again in 2009 and on both instances could not recommend their use. The publication of additional trials prompted a further update.
Authors' recommendations:
Although there is suggestive evidence that probiotics based on Lactobacillus may be effective in the prevention of CDAD, the evidence is not strong enough to be the basis for a general policy change. Accordingly, we cannot presently recommend routine use of probiotic Lactobacillus in the prevention of CDAD in hospitalized patients receiving antibiotics.
Details
Project Status:
Completed
Year Published:
2011
URL for published report:
http://www.mcgill.ca/tau/files/tau/muhc_tau_2011_54_probiotic.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Humans
- Lactobacillus
- Probiotics
- Anti-Bacterial Agents
- Clostridioides difficile
- Diarrhea
Contact
Organisation Name:
Technology Assessment Unit of the McGill University Health Centre (MUHC)
Contact Address:
Technology Assessment Unit of the MUHC, 536-5100 Boul. Maisonneuve O, Montreal, H4A 3T2
Contact Name:
eva.suarthana@mcgill.ca
Contact Email:
nisha.almeida@muhc.mcgill.ca
Copyright:
Technology Assessment Unit of the McGill University Health Centre (MUHC)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.