X-ray versus gamma irradiation of blood components for prevention of transfusion-associated graft versus host disease: a brief report

Sinclair A
Record ID 32012000045
Authors' objectives: The Technology Assessment Unit (TAU) was asked to review the available evidence in order to determine whether the two technologies were comparable in terms of effectiveness. (Comparison of costs has been carried out by the Biomedical Engineering Department.)
Authors' recomendations: No studies have been identified that directly compare the effectiveness of X-ray and gamma irradiation for the purpose of irradiating blood to eliminate TA-GvHD. On the basis of an understanding of the mechanism of disease and considerable data on cell response to ionizing radiation, it is expected that X-rays and gamma rays would have equivalent effectiveness in ablating the proliferative potential of cells responsible for TA-GvHD. The Joint Professional Advisory Committee of the UK Transfusion Services on blood components has recommended X-ray irradiation as a suitable, safe alternative that is equivalent to gamma ray irradiation. The capacity of both machines being investigated by the MUHC should be sufficient to meet the annual demand.
Project Status: Completed
Year Published: 2011
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Humans
  • Gamma Rays
  • X-Rays
  • Blood Transfusion
  • Graft vs Host Disease
Organisation Name: Technology Assessment Unit of the McGill University Health Centre (MUHC)
Contact Address: Technology Assessment Unit of the MUHC, Centre for Outcomes Research and Evaluation (CORE), Research Institute of the McGill University Health Centre, 5252 boul. de Maisonneuve, Bureau 3F.50, Montreal, Quebec H4A 3S5
Contact Name: nandini.dendukuri@mcgill.ca
Contact Email: nandini.dendukuri@mcgill.ca
Copyright: Technology Assessment Unit of the McGill University Health Centre (MUHC)
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