Intraoperative radiation therapy. IPE-99/22 (Public report)

Agencia de Evaluacion de Tecnologias Sanitarias (AETS)
Record ID 32000008077
Authors' objectives:

Intraoperative radiation therapy (IORT) allows the administration of a large single dose of ionizing radiation in the operative bed, with the purpose of enhancing local control of selected malignant tumours. This technique allows a visual and palpable demarcation of the tumour coupled with the physical exclusion from the treatment field by displacement or protection with lead shields of normal tissues that are dose limiting.

The objective of this report is to assess the use of IORT in view of the available scientific evidence.

Authors' recommendations: The available studies show dependent results of the tumour type, their localization and stage. Although most of the results present clinical relevance they do not reach statistical significance. Therefore, it is necessary to revise the design of new studies and even the definition of the outcome end-points. For this reason, IORT application must be planned meticulously, establishing the duration of the surgical procedure in function of the localization of the tumour, placement of the radiation cone, and mobilization of organs and other normal structures outside the treatment field to reduce the possible complications.
Authors' methods: Review
Project Status: Completed
URL for project:
Year Published: 1999
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Spain
MeSH Terms
  • Intraoperative Care
  • Radiotherapy
  • Neoplasms
Organisation Name: Agencia de Evaluacion de Tecnologias Sanitarias
Contact Address: Jose Luis de Sancho Martin, Instituto de Salud "Carlos III", Calle Sinesio Delgado 6, Pabellon 4, 28029 Madrid, Spain. Tel: +34 9 1 822 2005; Fax: +34 9 1 387 7841;
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Copyright: Agencia de Evaluacion de Tecnologias Sanitarias (AETS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.