[Liquid-based cytology for screening of precursors of cervical cancer]

The Regional Health Technology Assessment Centre (HTA-centrum)
Record ID 32011001707
Authors' objectives:

Can liquid-based cytology improve the sensitivity and specificity for detecting severe cytological changes (CIN2 or more severe = CIN2+) in tissue samples, compared to conventional cytology (CC, Pap-smear) in connection with gynecological cytology control, and does liquid-based cytology lead to a decreased proportion of not assessible samples?

Authors' recommendations: There is strong scientific evidence that the introduction of liquid-based cytology, reduces the proportion of not assessible samples, and thus re-appointments for patients. There is limited scientific support that liquid-based cytology, increases the sensitivity and decreases the specificity, which would imply that more cases with severe cytological abnormalities are detected at the expense of an increased proportion of false positive samples. This could eventually lead to fewer cancer cases, but a certain increase in the volume of examinations.
Project Status: Completed
Year Published: 2008
English language abstract: An English language summary is available
Publication Type: Not Assigned
MeSH Terms
  • Cytological Techniques
  • Uterine Cervical Neoplasms
Organisation Name: The Regional Health Technology Assessment Centre
Contact Address: The Regional Health Technology Assessment Centre, Region Vastra Gotaland, HTA-centrum, Roda Straket 8, Sahlgrenska Universitetssjukhuset, 413 45 GOTHENBORG, Sweden
Contact Name: hta-centrum@vgregion.se
Contact Email: hta-centrum@vgregion.se
Copyright: The Regional Health Technology Assessment Centre (HTA-centrum), Region Vastra Gotaland
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