Use of cisapride in patients with non-ulcer dyspepsia: a meta-analysis of randomized trials

Shukla VK, Otten N, Dube C, Moher D
Record ID 32000008074
English, French
Authors' objectives:

To determine the relative effectiveness of cisapride in the treatment of non-ulcer dyspepsia in comparison to placebo, H2-antagonists (H2RA) and proton pump inhibitors (PPI).

Authors' results and conclusions: Cisapride was found to be more effective than placebo [odds ratio(OR) 4.58; 95% confidence interval (CI) 3.58-5.85 for excellent outcome and OR 4.25; 95%CI 3.42-5.27 for excellent or good outcome]. Significant heterogeneity was observed across the studies in both cases. Results were sensitive to study quality, the presence or absence of placebo run-in period, country of publication, journal type and language. No significant difference was observed in outcomes between cisapride and H2-antagonists.
Authors' recommendations: Although cisapride was found to be effective in NUD and the effectiveness was comparable to H2-antagonists, the validity of the results on effectiveness of cisapride is uncertain because of systematic bias in the studies.
Authors' methods: Overview
Project Status: Completed
Year Published: 2000
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Cisapride
  • Dyspepsia
Organisation Name: Canadian Coordinating Office for Health Technology Assessment
Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553, Fax: +1 613 226 5392;
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Copyright: Canadian Coordinating Office for Health Technology Assessment
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