Use of cisapride in patients with non-ulcer dyspepsia: a meta-analysis of randomized trials
Shukla VK, Otten N, Dube C, Moher D
Record ID 32000008074
English, French
Authors' objectives:
To determine the relative effectiveness of cisapride in the treatment of non-ulcer dyspepsia in comparison to placebo, H2-antagonists (H2RA) and proton pump inhibitors (PPI).
Authors' results and conclusions:
Cisapride was found to be more effective than placebo [odds ratio(OR) 4.58; 95% confidence interval (CI) 3.58-5.85 for excellent outcome and OR 4.25; 95%CI 3.42-5.27 for excellent or good outcome]. Significant heterogeneity was observed across the studies in both cases. Results were sensitive to study quality, the presence or absence of placebo run-in period, country of publication, journal type and language. No significant difference was observed in outcomes between cisapride and H2-antagonists.
Authors' recommendations:
Although cisapride was found to be effective in NUD and the effectiveness was comparable to H2-antagonists, the validity of the results on effectiveness of cisapride is uncertain because of systematic bias in the studies.
Authors' methods:
Overview
Details
Project Status:
Completed
URL for project:
https://www.ccohta.ca/pubs/index.html
Year Published:
2000
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Cisapride
- Dyspepsia
Contact
Organisation Name:
Canadian Coordinating Office for Health Technology Assessment
Contact Address:
600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553, Fax: +1 613 226 5392;
Contact Name:
requests@cadth.ca
Contact Email:
requests@cadth.ca
Copyright:
Canadian Coordinating Office for Health Technology Assessment
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.