[Cost-effectiveness analysis of population screening tests for colorectal cancer: systematic review of the efficacy and safety]

Calcerrada Diaz-Santos N, Valentin Lopez B, Blasco Amaro JA
Record ID 32011001557
Authors' objectives:

To assess the efficacy/effectiveness/safety of different screening colorectal cancer tests in average risk people. Comparative evaluation of screening tests: fecal occult blood test (FBOT), flexible sigmoidoscopy and colonoscopy. To analyse emergent technologies such as computed tomographic colonography (CTC).

Authors' recommendations: High-quality evidence was found that screening with the guaiac FOBT, haemoccult, reduce mortality in CRC. The available data are not enough to determine which FOBT (guaiac-based tests or immunochemical) has the highest sensitivity and specificity at this time.No RCT has been completed providing mortality data relating to flexible sigmoidoscopy screening.The colonoscopy has been used principally as secondary screening tool.There is not enough evidence demostrating that combined FOBT and flexible sigmoidoscopy obtain a greater reduction in CRC mortality compared to either modality alone.Based on the current evidence, CTC cannot be proposed for colorectal cancer screening in average risk population.
Project Status: Completed
Year Published: 2008
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Spain
MeSH Terms
  • Colorectal Neoplasms
  • Mass Screening
Organisation Name: Unidad de Evaluacion de Tecnologias Sanitarias
Contact Address: Elena Andradas Aragones, Unidad de Evaluacion de Tecnologias Sanitarias, Agencia Lain Entralgo, C/ Gran Via, 27, 8a, ES-28013 Madrid, Spain. Tel: +34 91 3089418; Fax: +34 91 3089458;
Contact Name: elena.andradas@salud.madrid.org
Contact Email: elena.andradas@salud.madrid.org

Unidad de Evaluacion de Tecnologias Sanitarias (UETS)

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