[Oxygen carriers. Production of red blood cells from human embryonic stem cells]

Aguado Romeo MJ, Llanos Mendez A
Record ID 32011001539
Spanish
Authors' objectives: The culture of human embryonic stem cells is outlined as a potential source for the large scale production of erythrocytes with the capacity to carry oxygen, as they behave biologically and functionally like mature erythrocytes. The recovered works are studies in the experimental phase. No studies into the effectiveness of the transfusion of cultured erythroid cells, in animals or in humans, were found. Other oxygen carriers have been ineffective, such as perfluorocarbon emulsions, modified haemoglobin solutions, recombinant haemoglobin and others of artificial origin. Possible benefits of the transfusion of erythrocytes obtained by the culture of human embryonic stem cells would be to eliminate, at least partly, the problems of compatibility and transmission of diseases related to the traditional blood transfusion, and to replace the current source, the ever diminishing voluntary human donors. Technological limitations still persist: red cells with fundamentally embryonic and foetal haemoglobin chains and few adult chains are obtained (those that release O2 more easily) and which have antigenic determinants, therefore they are not of the universal donor type. The quantity of globin chains obtained is inferior to that which exists in the red cells of an adult individual, and in hypoxia situations this could mean less oxygen availability and therefore it is an aspect pending improvement.
Details
Project Status: Completed
URL for project: https://www.aetsa.org/publicacion/transportadores-de-oxigeno-obtencion-de-hematies-a-partir-del-cultivo-de-celulas-embrionarias-humanas/
Year Published: 2010
URL for published report: https://www.aetsa.org/download/publicaciones/antiguas/AETSA_2007-02-18_Oxigeno.pdf
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Spain
MeSH Terms
  • Embryonic Stem Cells
Contact
Organisation Name: Andalusian Health Technology Assessment Area
Contact Address: Area de Evaluacion de Tecnologias Sanitarias Sanitarias de Andalucia (AETSA) Avda. Innovación, s/n Edificio Arena 1. Sevilla (Spain) Tel. +34 955 006 309
Contact Name: aetsa.csalud@juntadeandalucia.es
Contact Email: aetsa.csalud@juntadeandalucia.es
Copyright: Andalusian Agency for Health Technology Assessment (AETSA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.