Tandem autologous peripheral blood stem cell transplantation for neuroblastoma

Record ID 32011001501
Authors' objectives:

Neuroblastoma is a cancer that arises in immature nerve cells and primarily affects infants and children. Approximately 70% of patients with neuroblastoma have metastatic disease at diagnosis. Although some progress has been made in the treatment of this disease over the past 40 years, fewer than 35% of high-risk patients will survive for 5 years without recurrence. The current standard therapy for high-risk neuroblastoma is based on a regimen of multicycle, multiagent induction chemotherapy; autologous peripheral blood stem cell (PBSC) collection early in induction; testing of the PBSC product for neuroblastoma contamination; organ-sparing surgical resection of primary tumor; consolidation therapy with high-dose chemotherapy (HDC) and single autologous PBSC rescue (PBSCR); local radiation therapy before or after the autologous PBSCR, sometimes followed by total body irradiation (TBI); biologic treatment with 13-cis-retinoic acid (CRA); and immunotherapy with antidisialoganglioside (anti-GD2) antibody. The introduction of autologous PBSC has allowed for dose escalation of effective anti-neuroblastoma agents beyond marrow suppression, significantly improving the outcome when compared with conventional chemotherapy alone. However, the overall event-free survival (EFS) remained less than 30% to 40%. In this context, some investigators examined the effectiveness of further intensifying consolidation therapy with tandem HDC and PBSCR to improve the outcome in high-risk neuroblastoma patients.

Project Status: Completed
Year Published: 2011
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: United States
MeSH Terms
  • Humans
  • Neuroblastoma
  • Peripheral Blood Stem Cell Transplantation
  • Transplantation, Autologous
Organisation Name: HAYES, Inc.
Contact Address: 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218
Contact Name: saleinfo@hayesinc.com
Contact Email: saleinfo@hayesinc.com
Copyright: 2011 Winifred S. Hayes, Inc
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