The care and management of wounds represent a substantial healthcare challenge, especially for chronic, nonhealing wounds. In the United States, it is estimated that 1.3 to 3 million individuals have pressure ulcers and as many as 10% to 15% of the 20 million individuals with diabetes are at risk of developing diabetic ulcers, including difficult-to-treat lower extremity ulcers, one of the most serious complications of diabetes. Powered negative pressure wound therapy (NPWT) has been investigated for the adjunct treatment of acute, subacute, and chronic wounds that are refractory to standard treatment. NPWT promotes healing in various types of open wounds by continuously removing exudate through the creation of a vacuum (negative pressure) and a secure seal at the wound site. Clinical trials have demonstrated that NPWT is safe and efficacious for wound healing, and is superior to modern moist dressings. Although widely available, powered NPWT devices are bulky, restrictive of patient activity, difficult to procure in the outpatient setting, expensive, and timeconsuming to apply.