Authors' recommendations: The results of the clinical outcomes in the selected studies varied. One meta-analysis found similar rates of MI and mortality, but higher stroke rates for octogenarians in the CAS group compared with the CEA group. CAS was associated with a greater recurrent carotid stenosis and re-stenosis rates compared with CEA across all studies included in one systematic review, and a positive correlation between women and risk of carotid artery stenting or stroke was not identified in one RCT. One meta-analysis reported differences in the stroke or death rate between both groups. The relative risk of patient adverse events and MI rate were significantly higher for CAS compared with CEA. The economic evaluations suggested that CAS had a higher average cost compared with CEA.According to the current literature, CAS is associated with an increased risk of stroke, MI, recurrent carotid stenosis, and re-stenosis and patient adverse events and higher average costs compared with CEA. Two large RCTs are on-going, and their results have not been published.

Project Status: Completed

URL for project: http://www.cadth.ca/media/pdf/L0130_CAS_vs._Endarterectomy_final.pdf

Year Published: 2009

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Canada

Organisation Name: Canadian Agency for Drugs and Technologies in Health

Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;

Contact Name: requests@cadth.ca

Contact Email: requests@cadth.ca

Copyright: Canadian Agency for Drugs and Technologies in Health (CADTH)