Remote ischemic conditioning: a review of the clinical effectiveness
Canadian Agency for Drugs and Technologies in Health
Record ID 32011001179
English
Authors' recommendations:
One systematic review and meta-analysis that included four RCTs, and eight additional RCTs that met the inclusion criteria were identified. Remote conditioning has been studied mostly in a pre-operative setting when the risk of experiencing an ischemic event is high. Only two studies were found that applied remote conditioning induced with limb ischemia in patients experiencing an acute myocardial infarction.Mostly surrogate outcomes were measured. In the pre-conditioning studies, only two studies reported morbidity outcomes. The CRISP stent study showed that RIPC patients had statistically significantly less chest pain during stenting, and that the rate of major adverse cardiac and cerebral events were statistically significant lower at six months. More studies measuring short-term and long-term morbidity and mortality are required to determine the clinical effectiveness of remote conditioning in any clinical setting.
Details
Project Status:
Completed
Year Published:
2010
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Humans
- Ischemic Postconditioning
- Ischemic Preconditioning, Myocardial
- Myocardial Reperfusion Injury
Contact
Organisation Name:
Canadian Agency for Drugs and Technologies in Health
Contact Address:
600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;
Contact Name:
requests@cadth.ca
Contact Email:
requests@cadth.ca
Copyright:
Canadian Agency for Drugs and Technologies in Health (CADTH)
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