Drug therapy for prophylactic and post-exposure treatment of H1N1: a review of the comparative clinical and cost-effectiveness
Canadian Agency for Drugs and Technologies in Health
Record ID 32011001167
English
Authors' recommendations:
In summary, based on the limited clinical evidence identified, oseltamivir appears to be less effective than other neuraminidase inhibitors for the treatment of H1N1 infection due to strains that have the H274Y mutation. Data from two Japanese studies suggest that, in the absence of the H274Y mutation, the clinical effectiveness of oseltamivir and zanamivir was comparable for the treatment of influenza due to H1N1 infection. The relevance of these observations to clinical practice or policy decisions about the use of oseltamivir and zanamivir for post-exposure treatment of H1N1 infection may be influenced by the prevalence of H274Y mutation in H1N1 strains circulating in a particular area. H1N1 is resistant to the anti-viral amantadine. No literature was identified from which to draw conclusions about the comparative clinical effectiveness of antiviral agents for post-exposure prophylaxis of H1N1 or about their cost-effectiveness in the prophylactic and post-exposure treatment of H1N1.
Details
Project Status:
Completed
Year Published:
2010
URL for published report:
n/a
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Antiviral Agents
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Post-Exposure Prophylaxis
Contact
Organisation Name:
Canadian Agency for Drugs and Technologies in Health
Contact Address:
600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;
Contact Name:
requests@cadth.ca
Contact Email:
requests@cadth.ca
Copyright:
<p>Canadian Agency for Drugs and Technologies in Health (CADTH)</p>
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