Corneal collagen cross-linking using riboflavin and ultraviolet-A for corneal thinning disorders

Pron G, Ieraci I, Kaulback K
Record ID 32011001012
English
Authors' objectives:

The main objectives for the evidence analysis were to determine the safety and effectiveness of photochemical corneal collagen cross-linking with riboflavin (vitamin B2) and ultraviolet-A radiation, referred to as CXL, for the management of corneal thinning disease conditions. The comparative safety and effectiveness of corneal cross linking with other minimally invasive treatmenst such as intrastromal corneal rings was also reviewed. The Medical Advisory Secretariat (MAS) evidence–based analysis was performed to support public financing decisions.

Authors' recommendations: OHTAC recommends the following with regard to corneal collagen crosslinking:1. Based on moderate quality evidence that corneal collagen cross-linking effectively stabilizes the underlying disease process, OHTAC recommends that corneal collagen cross-linking be made available to patients with corneal thinning disorders such as keratoconus that are progressive in nature.2. As corneal collagen cross-linking does not always improve visual acuity, adjunctive procedures such as intrastromal corneal ring segments, may need to be considered for visual rehabilitation and to avoid a corneal transplant.
Details
Project Status: Completed
Year Published: 2011
URL for published report: http://www.hqontario.ca/en/mas/tech/pdfs/2011/rev_CXL_November.pdf
URL for additional information: http://www.hqontario.ca/en/mas/mas_ohtas_tech_cxl_20111122.html
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Collagen
  • Cornea
  • Corneal Topography
  • Riboflavin
  • Ultraviolet Rays
Contact
Organisation Name: Medical Advisory Secretariat
Contact Address: Medical Advisory Secretariat, 20 Dundas Street West, 10th Floor, Toronto, ON M5G 2N6 CANADA. Tel: 416-314-1092l; Fax: 416-325-2364;
Contact Name: MASinfo.moh@ontario.ca
Contact Email: MASinfo.moh@ontario.ca
Copyright: Medical Advisory Secretariat, Ontario Ministry of Health and Long-Term Care (MAS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.