Epoetin and darbepoetin for managing anemia in patients undergoing cancer treatment: comparative effectiveness update
Grant MD, Piper M, Bohlius J, Tonia T, Robert N, Vats V, Bonnell C, Ziegler KM, Aronson N
Record ID 32011001010
English
Authors' objectives:
To update the 2006 systematic review of the comparative benefits and harms of erythropoiesis-stimulating agent (ESA) strategies and non-ESA strategies to manage anemia in patients undergoing chemotherapy and/or radiation for malignancy (excluding myelodysplastic syndrome and acute leukemia), including the impact of alternative thresholds for initiating treatment and optimal duration of therapy.
Authors' recommendations:
Results of this update were consistent with the 2006 review. ESAs reduced the need for transfusions and increased the risk of thromboembolism. FACT-Fatigue scores were better with ESA use but the magnitude was less than the minimal clinically important difference. An increase in mortality accompanied the use of ESAs. An important unanswered question is whether dosing practices and overall ESA exposure might influence harms.
Details
Project Status:
Completed
Year Published:
2013
URL for published report:
http://www.effectivehealthcare.ahrq.gov/ehc/products/170/1480/cancer-anemia-treatment-report-130425.pdf
URL for additional information:
http://www.effectivehealthcare.ahrq.gov/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=1481
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Comparative Effectiveness Research
- Anemia
- Erythropoietin
- Neoplasms
Contact
Organisation Name:
Agency for Healthcare Research and Quality
Contact Address:
The Evidence-based Practice Center (EPC) Program, Center for Evidence and Practice Improvement, 5600 Fishers Lane, Rockville, MD 20857, USA. Tel: +1 301 427 1550
Contact Name:
The EPC Program
Contact Email:
epc@ahrq.hhs.gov
Copyright:
<p>Agency for Healthcare Research and Quality (AHRQ)</p>
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.