Nicotine withdrawal symptoms are extremely prevalent among patients attempting to quit and are often cited as the reason for relapse. Nicotine replacement therapy (NRT) is designed to facilitate smoking cessation by providing nicotine through alternative delivery methods, thereby reducing or eliminating withdrawal symptoms without the ill effects of tobacco smoke inhalation. NRT is available in the United States as nasal spray, inhaler, gum lozenges/tablets, and transdermal patch; additional formulations, including a nicotine pouch, nicotine water, sublingual tablets, nicotine lollipops, and nicotine mouth spray, are available in countries outside of the United States (not FDA approved). The nicotine patch is worn on the skin throughout the day or day and night and delivers a steady dose of nicotine transdermally. Unlike other NRT formulations, the nicotine patch does not allow for direct dose control by its user.