Nicotine withdrawal symptoms are extremely prevalent among patients attempting to quit, and are often cited as the reason for relapse. Nicotine replacement therapy (NRT) is designed to facilitate smoking cessation by providing nicotine through alternative delivery methods, thereby reducing or eliminating withdrawal symptoms without the ill effects of tobacco smoke inhalation. NRT is available in the United States as nasal spray, inhaler, gum lozenges/tablets, and transdermal patch; additional formulations including a nicotine pouch and nicotine mouth spray are available in some European countries. The speed of nicotine delivery to the brain is critical to both its addictive and rewarding effects. Absorption of nicotine by the buccal mucosa (inhaler) and nasal membranes (nasal spray) is relatively slow, with peak plasma concentrations reached in 4 to 15 minutes, and the rapid rise and decline in nicotine arterial plasma concentrations typical for cigarette smoking are not achieved with these products, thus limiting the likelihood that they will be abused.