Implantable cardioverter defibrillators: arrhythmias. A rapid and systematic review
Parkes J, Bryant J, Milne R
Record ID 32000000925
English
Authors' objectives:
The aim of this review is to provide a rapid review of the clinical effectiveness and cost-effectiveness of implantable cardioverter defibrillators (ICDs) compared with conventional therapy, in patients at risk of sudden cardiac death (SCD) from arrhythmias.
Authors' results and conclusions:
Seven RCTs on effectiveness the majority of which were of good quality, eight cost-effectiveness analyses most of which were older studies and based on non-UK data, and two good-quality literature reviews one of which was a critical appraisal of the literature of effectiveness and cost-effectiveness of ICD therapy, and the other a review of the cost-effectiveness of ICD therapy. These showed changes in absolute risk of total mortality ranging from an increase of 1.7% to a reduction of 22.8% (relative risk reductions of -7% to +54%).
Authors' recommendations:
Estimated benefits from RCT data are 0.23-0.8 additional years of life with ICD therapy compared with anti-arrhythmic drug therapy.
Authors' methods:
Systematic review
Details
Project Status:
Completed
URL for project:
http://www.hta.ac.uk/1177
Year Published:
2000
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Anti-Arrhythmia Agents
- Costs and Cost Analysis
- Defibrillators, Implantable
Contact
Organisation Name:
NIHR Health Technology Assessment programme
Contact Address:
NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
journals.library@nihr.ac.uk
Contact Email:
journals.library@nihr.ac.uk
Copyright:
2009 Queen's Printer and Controller of HMSO
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