Vaginal brachytherapy for treatment of women with high-intermediate risk of endometrial cancer

Ellery B, Hiller JE
Record ID 32011000622
Authors' recommendations: The included evidence for the safety and effectiveness contained one high-level study (Nout et al 2010) which indicated VBT has similar oncological and survival outcomes, but lower toxic effects when compared to EBRT. Thus VBT potentially offers improved quality of life for endometrial cancer patients. Importantly, one included study (Byrd et al 2008) reported outcomes and cited further sources which suggest that the benefit of post-operative radiotherapy remains uncertain. Although EBRT and VBT provide similar improvement in vaginal recurrence, it is not clear that this outcome translates to overall or disease-free survival exceeding surgery alone. If radiotherapy is to be performed at all, the indication at present is that prophylactic VBT should be sufficient to reduce the majority of vaginal recurrence following total abdominal hysterectomy with bilateral salpingo-oophorectomy while resulting in fewer toxic effects than EBRT.As vaginal brachytherapy is already an established technology in Australia, no further evaluation on behalf of HealthPACT is warranted.
Project Status: Completed
Year Published: 2010
URL for published report: Not Available
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Australia
MeSH Terms
  • Brachytherapy
  • Risk Factors
  • Vagina
Organisation Name: Adelaide Health Technology Assessment
Contact Address: School of Public Health, Mail Drop 545, University of Adelaide, Adelaide SA 5005, AUSTRALIA, Tel: +61 8 8313 4617
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Copyright: Adelaide Health Technology Assessment (AHTA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.