Liquid-based cytology in cervical screening: a rapid and systematic review

Payne N, Chilcott J, McGoogan E
Record ID 32000000894
Authors' objectives:

To review the available evidence on the effectiveness and cost-effectiveness of liquid-based cytology in cervical screening.

Authors' results and conclusions: Effectiveness: There is some evidence that liquid-based cytological methods offer the following advantages over traditional smear techniques: - a reduction in the proportion of inadequate specimens - an improvement in sensitivity - a possible reduction in specimen interpretation times.
Authors' recommendations: From the evidence available, it is likely that the liquid-based cytology technique will reduce the number of false-negative test results, reduce the number of unsatisfactory specimens and may decrease the time needed for examination of specimens by cytologists. It is not possible to be certain whether this will reduce the incidence of invasive cancer, but modelling studies have suggested that this would occur. In this review, it became clear that increasing the coverage of the programme, and the use of more effective cervical specimen collection devices are also important ways of reducing the burden of the invasive cervical cancer. The use of automated image analysis devices, and of other testing of the specimens (such as for human papillomavirus) have not been covered in this review.
Authors' methods: Systematic review
Project Status: Completed
URL for project:
Year Published: 2000
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • False Negative Reactions
  • Mass Screening
  • Predictive Value of Tests
  • Vaginal Smears
  • Uterine Cervical Neoplasms
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
Contact Email:
Copyright: 2009 Queen's Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.