An evaluation of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina

Agency for Healthcare Research and Quality
Record ID 32000000887
English
Authors' objectives:

The aim of this report is to assess the use of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina.

Authors' recomendations: Beta-blockers were associated with fewer episodes of angina when compared with calcium antagonists in general and with nifedipine in particular. Important differences in mortality could not be determined because the trials were short in duration (median 4 weeks). Fewer adverse events leading to study withdrawal occurred with beta-blockers compared with calcium antagonists. Commonly reported side effects were similar or greater in the calcium antagonists group compared with the beta-blocker group. There were no obvious differences in any outcome measures between beta-blockers and non-nifedipine calcium antagonists. Few studies compared long-acting nitrates with beta-blockers or with calcium antagonists. Randomized trials of alternative therapies for patients with stable angina were too small and too few to provide conclusive findings.
Authors' methods: Review
Details
Project Status: Completed
Year Published: 1999
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: United States
MeSH Terms
  • Adrenergic beta-Antagonists
  • Calcium Channel Blockers
  • Angina Pectoris
Contact
Organisation Name: Agency for Healthcare Research and Quality
Contact Address: Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA. Tel: +1 301 427 1610; Fax: +1 301 427 1639;
Contact Name: martin.erlichman@ahrq.hhs.gov
Contact Email: martin.erlichman@ahrq.hhs.gov
Copyright: Agency for Healthcare Research and Quality (AHRQ)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.