[Prevention of infection after knee arthroplasty]
Gorenoi V, Schoenermark MP, Hagen A
Record ID 32011000456
German
Authors' objectives:
To address questions regarding the medical effectiveness, cost effectiveness, and ethical, social, and legal aspects related to using interventions to prevent infections after knee arthroplasty.
Authors' recommendations:
A systematic literature search yielded 1030 hits. Ten publications were included in the analysis, based on predefined inclusion and exclusion criteria. The report does not find high-level evidence for the effectiveness of different hygiene interventions. Most of the unspecific interventions are recommended on the basis of results from nonrandomized controlled trials, from studies for other clinical indications and/or clinically nonrelevant endpoints, or on the basis of expert opinion. A high level of evidence on the effectiveness of intravenous prophylaxis with antibiotics in knee arthroplasty is also missing. The recommendations use evidence on the intravenous antibiotic prophylaxis transferred from RCT in hip arthroplasty to the arthroplasty of all joints, including knee replacement. Moreover, no evidence is found for differences in the effectiveness between various antibiotics in knee arthroplasty. The report finds strong hints for the effectiveness of antibiotics in cement in addition to intravenous prophylaxis. However, evidence of the effectiveness may be accepted only for operating rooms without clean-air measures. The cost effectiveness of different interventions to prevent infections in knee arthroplasty remains unclear. There are no signs for concern regarding any ethical, social, and/or legal consequences in using interventions to prevent infections in knee arthroplasty.
Details
Project Status:
Completed
URL for project:
http://portal.dimdi.de/de/hta/hta_berichte/hta264_summary_en.pdf
Year Published:
2010
URL for published report:
http://portal.dimdi.de/de/hta/hta_berichte/hta264_bericht_de.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Germany
MeSH Terms
- Postoperative Care
- Skin Care
- Surgical Wound Infection
- Wound Healing
Contact
Organisation Name:
German Agency for HTA at the German Institute for Medical Documentation and Information
Contact Address:
German Agency for Health Technology Assessment at the German Institute for Medical Documentation and Information, Waisenhausgasse 36-38a, D-50676 Cologne Germany
Contact Name:
dahta@dimdi.de
Contact Email:
dahta@dimdi.de
Copyright:
German Agency for Health Technology Assessment at the German Institute for Medical Documentation and Information (DAHTA@ DIMDI)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.