BRATS 07: Deferasirox for the treatment of iron overload

Department of Science and Technology - Brazilian Health Technology Assessment General Coordination (DECIT-CGATS), National Health Surveillance Agency (ANVISA) and National Supplementary Health Agency (ANS)
Record ID 32011000254
English
Authors' objectives:

The topic of this bulletin is a drug which was recently incorporated into the Unified Health System, that is, deferasirox. Administered orally, this drug is indicated for the treatment of chronic iron overload, due to blood transfusions, in adult and pediatric patients.
Desferoxamin meets a larger number of indications and is associated with a survival period of approximately 50 years; however, adherence to the treatment is low due to pain and subcutaneous infusion intolerance. Although administered orally, deferipron’s use is limited due its adverse reactions profile.

Authors' recommendations: Due to the low prevalence, there is little evidence on prognostic implications of iron overload in patients with falciform disease or mielodysplasia syndrome, as well as on benefits of iron chelators in such patients. Besides, recurrent transfusions may not be necessary in patients with falciform anaemia and patients with mielodysplasia syndrome normally elders and may not survive to accumulate iron bordering with the overload. As such, implications related to iron overload in patients with falciform disease and mielodysplasia syndrome may not have the same consequences as the ones observed in patients with beta thalassaemia.
Details
Project Status: Completed
URL for project: http://200.214.130.94/rebrats/publicacoes/BRATS%20_07_ing.pdf
Year Published: 2009
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Brazil
MeSH Terms
  • Chelation Therapy
  • Iron
  • Iron Chelating Agents
  • Iron Overload
Contact
Organisation Name: Coordenação-Geral de Fomento à Pesquisa e Avaliação de Tecnologias em Saúde, Departamento de Ciência e Tecnologia
Contact Address: Ministerio da Saude, Secretaria de Ciencia, Tecnologia e Insumos Estrategicos, Departamento de Ciencia e Tecnologia, Esplanada dos Ministerios, Edificio sede; bl "G" - 8 andar - SL 834, CEP: 70058-900, Brasilia, DF Brazil, Tel: +55 61 3315 3197 Fax: +55 61 3315 3850
Contact Name: suzanne.jacob@saude.gov.br
Contact Email: suzanne.jacob@saude.gov.br
Copyright: Secretaria de Ciencia, Tecnologia e Insumos Estrategicos, Departamento de Ciencia e Tecnologia (DECIT-CGATS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.