Etanercept (Enbrel(R))

Alberta Heritage Foundation for Medical Research
Record ID 32000000855
Authors' objectives: This report aims to summarise the available evidence on the use of etanercept (Enbrel(R)) in the treatment of rheumatoid arthritis.
Authors' recommendations: Enbrel(R) has been approved by the FDA for treatment of juvenile rheumatoid arthritis and severe to moderate rheumatoid arthritis. It is for use in patients who have an inadequate response to one or more disease-modifying anti-rheumatic drugs. Enbrel(R) inhibits the binding of tumor necrosis factor (TNF) to its receptor. TNF is a protein secreted by certain immunoregulatory cells. Normally this protein helps fight infection; however in an autoimmune disease it contributes to the inflammation which destroys joints. In a study, 69 patients aged 4 to 17 years were treated for three months with Enbrel(R). These patients had discontinued treatment with methotrexate due to intolerance or poor response. Fifty-one patients (74%) showed improvement. This group of responders was then divided into two groups to continue receiving Enbrel(R) or placebo. Those who continued on the drug remained stable, while those on placebo deteriorated. When restarted on Enbrel(R), the placebo group improved again.
Authors' methods: Overview
Project Status: Completed
Year Published: 2000
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Arthritis, Rheumatoid
Organisation Name: Institute of Health Economics
Contact Address: 1200, 10405 Jasper Avenue, Edmonton, Alberta, Canada, T5J 3N4. Tel: +1 780 448 4881; Fax: +1 780 448 0018;
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Copyright: Alberta Heritage Foundation for Medical Research (AHFMR)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.