Assessment of baseline age-specific antibody prevalence and incidence of infection to novel influenza A/H1N1 2009
Hardelid P, Andrews NJ, Hoschler K, Stanford E, Baguelin M, Waight PA, Zambon M, Miller E
Record ID 32011000120
English
Authors' objectives:
Studies were designed to provide an assessment of pre-pandemic baseline immunity in the population and the prevalence of antibody in the population after the first and second waves, and thereby deduce incidence of infection during successive waves of the pandemic. The specific objectives were to document:
the prevalence of cross-reactive antibodies to H1N1 2009 by age group
the age-specific incidence of infection by month as the pandemic progressed, by measuring increases in the proportion of individuals with antibodies to H1N1 2009 by age.
Authors' recommendations:
Serological analysis of appropriately structured, age-stratified and geographically representative samples can provide an immense amount of information to set in context other measures of pandemic impact in a population and provide the most accurate measures of population exposures. National scale seroepidemiology studies require cross-agency coordination, multidisciplinary working and considerable scientific resource.
Details
Project Status:
Completed
URL for project:
http://www.hta.ac.uk/fullmono/mon1455.pdf#nameddest=article03
Year Published:
2010
URL for published report:
http://www.hta.ac.uk/project/2226.asp
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Child
- Child, Preschool
- Confidence Intervals
- Female
- Geography
- Incidence
- Infant
- Infant, Newborn
- Likelihood Functions
- Logistic Models
- Male
- Middle Aged
- Population Surveillance
- Prevalence
- Risk Factors
- Seroepidemiologic Studies
- State Medicine
- Statistics as Topic
- Young Adult
- Antibodies, Viral
- Cross Reactions
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
Contact
Organisation Name:
NIHR Health Technology Assessment programme
Contact Address:
NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
journals.library@nihr.ac.uk
Contact Email:
journals.library@nihr.ac.uk
Copyright:
2010 Queen's Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.