Observational study to investigate vertically acquired passive immunity in babies of mothers vaccinated against H1N1v during pregnancy
Puleston RL, Bugg G, Hoschler K, Konje J, Thornton J, Stephenson I, Myles P, Enstone J, Augustine G, Davis Y, Zambon M, Nicholson KG, Nguyen-Van-Tam JS
Record ID 32011000118
English
Authors' objectives:
The recent pandemic of 2009–10, although overall mild in impact, amply demonstrated that some individuals/groups are at increased risk of complications/death from influenza infection. Those at increased risk included pregnant women. Persuading patients to accept vaccination can be difficult, and in pregnancy there is rightly caution about providing any medical interventions unless the benefit outweighs the risk. This study was undertaken to determine if pregnant women vaccinated against A/H1N1v passed on humoral immunity to their unborn child and therefore would provide it with protection against acquiring influenza. Evidence that this was the case could be used by health policy-makers and clinicians to encourage women to accept protective vaccine in future pandemic influenza events, as well as seasonal influenza.
Authors' recommendations:
This study provides evidence that maternal vaccination against monovalent A/H1N1v can provide humoral immunity to the unborn child, which may protect the baby against acquisition of the infection early in infancy when treatment options for infection are limited (because antiviral medications and immunisation are not licensed, have theoretical unwanted effects or may not be effective in this age group). The results will provide support to policy-makers and clinicians in advocating immunisation for pregnant women in future influenza epidemic and pandemic events, and will help pregnant women to make informed choices about vaccination under such circumstances.
Details
Project Status:
Completed
Year Published:
2010
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Adult
- Confidence Intervals
- Female
- Incidence
- Infant Welfare
- Infant, Newborn
- Kaplan-Meier Estimate
- Maternal Welfare
- Mortality
- Multivariate Analysis
- Odds Ratio
- Poisson Distribution
- Pregnancy
- Prevalence
- Proportional Hazards Models
- Prospective Studies
- Risk Assessment
- Surveys and Questionnaires
- Immunity, Maternally-Acquired
- Immunization Programs
- Infectious Disease Transmission, Vertical
- Influenza A Virus, H1N1 Subtype
- Influenza Vaccines
- Influenza, Human
- Pandemics
Contact
Organisation Name:
NIHR Health Technology Assessment programme
Contact Address:
NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
journals.library@nihr.ac.uk
Contact Email:
journals.library@nihr.ac.uk
Copyright:
This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database.