Genetic testing for predisposition to inherited hypertrophic cardiomyopathy
BlueCross BlueShield Association
Record ID 32011000014
English
Authors' recommendations:
Evidence on the impact of genetic testing for predisposition to HCM is limited. Despite the limitations in evidence, predisposition testing can have benefits for two populations ofpatients. Testing of an index patient improves outcomes for close relatives at risk for HCM, by informing the subsequent testing of relatives.For individuals who are at risk for HCM, the utility of predisposition testing will vary depending on whether there is a known mutation in the family. When there is a knownmutation in the family, genetic testing will have benefits. The negative predictive value is very high in this situation; therefore a negative test will essentially rule out the familial predisposition to HCM and will negate the need for future diagnostic surveillance. When there is not a known mutation in the family, the predictive value of genetic testing is not sufficiently high to rule out the possibility of inheriting the familial predisposition to HCM.
Details
Project Status:
Completed
Year Published:
2009
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Blue Cross Blue Shield Insurance Plans
- Predictive Value of Tests
- Technology Assessment, Biomedical
- United States
- United States Food and Drug Administration
- Cardiomyopathy, Hypertrophic, Familial
- Genetic Predisposition to Disease
- Genetic Testing
Contact
Organisation Name:
BlueCross BlueShield Association
Contact Address:
BlueCross BlueShield Association, Technology Evaluation Center, 225 North Michigan Ave, Chicago, Illinois, USA. Tel: 888 832 4321
Contact Name:
tec@bcbsa.com
Contact Email:
tec@bcbsa.com
Copyright:
<p>BlueCross BlueShield Association (BCBS)</p>
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.