Efficacy and cost-effectiveness of a gentamicin-loaded collagen sponge as an adjuvant antibiotic prophylaxis for colorectal surgery
Pan I, Dendukuri N
Record ID 32010001783
English
Authors' recommendations:
A gentamicin-loaded collagen sponge appears to be promising in preventing surgical site infection following colorectal surgery, though there is a paucity of high-quality RCTs demonstrating this. It is possible that improved adherence to the oral and intravenous antibiotic protocol at the MUHC might lower the infection rate from the assumed value of 15% to a negligible risk that eliminates the need for further intervention. The cost-effectiveness of GCS depends on the assumed risk of infection.There is strongly suggestive evidence that use of gentamicin loaded collagen sponge is capable of lowering surgical site infection rates following colorectal surgery in patients already receiving prophylactic antibiotic treatment.The extent of the benefit that can be expected from the use of Collatamp will depend on the base rate of post-operative infections.When last examined, the use of prophylactic antibiotic for colorectal surgery at the MUHC was below optimal while the base infection rate was high (15%).
Details
Project Status:
Completed
URL for project:
http://www.mcgill.ca/files/tau/Collatamp_Colorectal_FINAL.pdf
Year Published:
2010
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Gentamicins
- Costs and Cost Analysis
- Colorectal Surgery
- Anti-Bacterial Agents
- Surgical Wound Infection
- Surgical Sponges
- Collagen
Contact
Organisation Name:
Technology Assessment Unit of the McGill University Health Centre (MUHC)
Contact Address:
Technology Assessment Unit of the MUHC, Centre for Outcomes Research and Evaluation (CORE), Research Institute of the McGill University Health Centre, 5252 boul. de Maisonneuve, Bureau 3F.50, Montreal, Quebec H4A 3S5
Contact Name:
nandini.dendukuri@mcgill.ca
Contact Email:
nandini.dendukuri@mcgill.ca
Copyright:
Technology Assessment Unit of the McGill University Health Centre (MUHC)
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