Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs
Booth RA, Ansari MT, Tricco AC, Loit E, Weeks L, Doucette S, Skidmore B, Hoch JS, Tsouros S, Sears M, Sy R, Karsh J, Mani S, Galipeau J, Yurkiewich A, Daniel R, Tsertsvadze A, Yazdi F
Record ID 32010001651
English
Authors' recommendations:
There is insufficient direct evidence regarding the effectiveness of pretesting of TPMT status in patients with chronic autoimmune diseases. Indirect evidence confirms strong association of leukopenia with lower levels of TPMT activity and carrier genotype already established in the literature.
Details
Project Status:
Completed
URL for project:
http://www.ahrq.gov/downloads/pub/evidence/pdf/tpmt/tpmt.pdf
Year Published:
2010
URL for published report:
http://www.ahrq.gov/clinic/tp/tpmttp.htm
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Autoimmune Diseases
- Azathioprine
- Costs and Cost Analysis
- Methyltransferases
- Sensitivity and Specificity
Contact
Organisation Name:
Agency for Healthcare Research and Quality
Contact Address:
Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA. Tel: +1 301 427 1610; Fax: +1 301 427 1639;
Contact Name:
martin.erlichman@ahrq.hhs.gov
Contact Email:
martin.erlichman@ahrq.hhs.gov
Copyright:
Agency for Healthcare Research and Quality (AHRQ)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.